I was wondering if you were aware of any risks of patients in a severe/bedridden state trying corticosteroids, i.e. if you had heard of them precipitating further crashes?
Although the second study does note that:
Although adverse symptoms reported by patients taking hydrocortisone were mild, suppression of adrenal glucocorticoid responsiveness was documented in 12 patients who received it vs none in the placebo group
I was also wondering what your opinion is on the fact that the drug is 2 months expired
The exception is doxycycline, which slowly breaks down into a toxic by-product, so should not be used after expiry.