Unnerving symptom

Hip

Senior Member
Messages
11,780
Likes
20,244
I was wondering if you were aware of any risks of patients in a severe/bedridden state trying corticosteroids, i.e. if you had heard of them precipitating further crashes?
I don't think there is enough research to say for sure, but I seen a couple of ME/CFS studies (here and here) that found low-dose corticosteroids taken for a few months did not result in any significant adverse effects, at least in that timeframe.

Although the second study does note that:
Although adverse symptoms reported by patients taking hydrocortisone were mild, suppression of adrenal glucocorticoid responsiveness was documented in 12 patients who received it vs none in the placebo group


I was also wondering what your opinion is on the fact that the drug is 2 months expired
Some research by the US military (who stockpile certain drugs for their own purposes) found that even years after their expiry dates, the drugs were still viable and chemically unchanged. So I would think most drugs are perfectly safe to use years after the expiry date.

The exception is doxycycline, which slowly breaks down into a toxic by-product, so should not be used after expiry.
 
Last edited:

outdamnspot

Senior Member
Messages
813
Likes
571
@Hip "Although adverse symptoms reported by patients taking hydrocortisone were mild, suppression of adrenal glucocorticoid responsiveness was documented in 12 patients who received it vs none in the placebo group"

What does that mean?
 

Hip

Senior Member
Messages
11,780
Likes
20,244
What does that mean?
I would think suppression of adrenal glucocorticoid responsiveness means that the glucocorticoid receptors, which are the receptors that respond to cortisol, became less sensitive and less responsive over time, as a result of low-dose corticosteroid treatment.

In other words, the body starts to compensate for the higher levels of cortisol due to supplementation by turning down the sensitivity of the glucocorticoid receptors.
 
Messages
76
Likes
220
Location
Ontario, Canada
Luckily you have some things in your bag for this journey: your body is an amazing survival tool. Right now it's operating on a high level, even if it doesn't make sense to us. There's logic behind its reasoning, for example why it reacts to certain things you eat or experience (sounds etc.) the way it does. If we could just understand it more... then we could help it.
That's the other positive thing: your body is made for survival and it will gladly embrace any little thing you give it. So it does not matter much if you do the exact best thing, you can do anything, and it only has to be a little good, and your body will take it and run with it in the right direction.
thank you for this, @WoolPippi . we need to remember that there is logic we aren't comprehending but that it isn't our enemy. :balanced:
 

outdamnspot

Senior Member
Messages
813
Likes
571
Okay, well I wanted to give an update of the past week. Interestingly enough, I was trying to work around my food tolerances by following a zero carb/Carnivore diet, but as I've mentioned elsewhere on here, that seems to result in profound weakness and fatigue pretty quickly. So, completely desperate, and feeling like my body was just craving something carby, I reintroduced peanut butter. It seems that when I start eating an inflammatory food again after a break, I actually get a massive surge in energy (probably due to cortisol release and/or it messing up my gut?). So for about a week, I felt completely normal (in the context of still having severe CFS) and could sit up for a few hours, fast normally between meals, watch Youtube, talk on the phone etc., and all the horrible low-cortisol symptoms like the ambient mental fear, inability to think, sleep through the night etc. disappeared.

After that, I crashed horribly and the peanut butter just made me feel profoundly weak and sick (it was horrifying to see the difference in functioning); so I cut it out and went ZC again, which isn't a solution either. So fearing I was at a dead-end, today I finally took the HC (about 3 hours ago, when I woke up at 2.30pm). I had eaten peanut butter because I was so hungry before bed, which disrupted my sleep and left me feeling very weak/low-cortisol/panicky and I was dreading the day. About 20 minutes after taking the dose, I noticed I started to feel very 'relaxed' ... benzos never worked for me, so I can't compare, but it was all the tension just disappeared from my body, along with that sense of mental fear and dread. I got up after 45 minutes and had a cup of coffee and didn't crash horribly. It doesn't feel like a stimulant (as @WoolPippi said it wouldn't) but I just feel more physically nourished, if that makes sense? After having an inflammatory food before bed, then adding coffee, I would normally be a panicked wreck right now. But I feel composed. Also, last time I started at a high-dose (20mg) and felt way too stimulated and also sick/overheated, but again, nothing like that .. just clearheaded. Anyway, my computer is having problems staying online so I just wanted to post this before it crashes but I did have a couple of follow-up questions too.
 

outdamnspot

Senior Member
Messages
813
Likes
571
Well, to continue my experience from yesterday: overall, I would say it was positive. The only issue is that I seemed to feel the 5mg dose suddenly wearing off after about 3 hours (my limbs became leaden, I felt more brain fogged, fatigued etc.), so I did take an additional 2.5mg before dinner. After that, I did a coffee enema (which I do daily) and ate; I experienced quite a lot of brain fog during the rest of the night, but my energy levels were a lot more stable and there was no sense I needed to re-dose. I felt a lot less panicked before bed, and slept through the night (in my low cortisol states, I can wake up every few hours, which is horrible).

Today is a little different, however. Since I slept better, I woke up feeling better and took a 5mg dose while in bed. As @WoolPippi the effects definitely kick in after 45 minutes; again, it isn't stimulation but clearheadedness, interior warmth etc. However, I feel less 'physically scaffolded' today; I have a strange sleepy brain fog, and some of my POTS/balance symptoms feel worse and it's a little difficult to sit up in bed (not due to fatigue, but I've had this horrible background 'rocking' sensation since getting sick). I know no one wants to give direct medical advice, since this is a self-conducted experiment, but is there a possible explanation for this? My questions are:

1. Regarding yesterday, is it normal to experience a dose wearing off? Is this an individual thing? Because I have no plans to exceed 5-10mg a day, but I was just wondering how a lower dose can help the entire day vs. people who need to dose 20mg+ divided up every few hours. Is it because these people more likely have Addison's/adrenal insufficiency and can't produce cortisol at any point, whereas I more likely just have low cortisol due to CFS (and therefore the HC upon waking might help 'kickstart' things)?

2. Do the effects of HC supplementation change over time? Is it possible there are just early side-effects? Regarding the POTS/rocking feeling/fog, what I've wondered is whether it's possible it's physically relaxing me and lowering adrenaline, and maybe exposing these problems, which do get worse in a 'relaxed' state? Or exposing some other requirement? I know some people take Fludrocortisone alongside HC.

3. I tried to search this but couldn't find much information, but is there a relationship between HC and things like food intolerances, MCAS etc.? Just curious because I'm continuing eating 'bad' foods like peanut butter because I don't want to put my body in a zero carb state, especially while trying the HC, but just wondering if these intolerances could improve at all.

If @Hip @WoolPippi or @Wayne could weigh in at all, I'd appreciate it :)

 
Messages
75
Likes
79
Dr. Edward Group recommends using intraMAX

https://www.globalhealingcenter.com/natural-health/what-is-adrenal-fatigue/


https://store.druckerlabs.com/intraMAXinfo_s/117.htm

It might be helpfull, i have used it also and feel it has health supporting features. I may not agree using iodine ,i mean using larger amounts , the detox/herx can be quite a trip :bang-head::aghhh::nervous: . Iodine in larger quantitys would probably cause mobilizing of chemicals that are known endocrine disruptors, but not sure about this thought, i had used a lot but, it do seems to mobilize also quite a lot toxins, so maybe not ideal time for it when adrenals are already crashed ?
 

WoolPippi

Senior Member
Messages
555
Likes
1,518
Location
Netherlands
Hi :)
1. Regarding yesterday, is it normal to experience a dose wearing off? Is this an individual thing? Because I have no plans to exceed 5-10mg a day, but I was just wondering how a lower dose can help the entire day vs. people who need to dose 20mg+ divided up every few hours. Is it because these people more likely have Addison's/adrenal insufficiency and can't produce cortisol at any point, whereas I more likely just have low cortisol due to CFS (and therefore the HC upon waking might help 'kickstart' things)?
Yes it is normal to experience the dose wearing off. It is so with most hormones, just think of insuline (carb sleepyness).
With hydrocortisone I experience it in 1,5 hours the first half of the day and this lengthens during the day.
The time of day when you take it influences whether you experience it hard or soft.

That you experience it at all is useful information. Unfortunately I can't help you interpret this knowledge atm. But it gives cause to think about what base level you naturally have; is the dose replacing a shortage and is the slinking back to suboptimal levels causing the feeling of wearing off? or are you overfeeding the system and crashing hard after a peak and does that cause the feeling? (analogue to a sugar peak and then wanting to snack more). I dunno. At least you know there's an effect.

2. Do the effects of HC supplementation change over time? Is it possible there are just early side-effects? Regarding the POTS/rocking feeling/fog, what I've wondered is whether it's possible it's physically relaxing me and lowering adrenaline, and maybe exposing these problems, which do get worse in a 'relaxed' state? Or exposing some other requirement? I know some people take Fludrocortisone alongside HC.
Effects of HC are dependent on day, temperature of the weather, your stress levels, how hard your stomach has to work (fat and protein digestion), time of day, whether you're feeling cold etc.

What also might occur is that your system is put into gear by the HC (your digestion, your waste removal, your bowels) but you still have a blocked waste route. Analogue to people taking vitamin B12 but not having chelated heavy metals or taking care of their liver detox phases.

Taking HC will likely increase cholesterol (after all, you're replacing the stuff your body makes of cholesterol) and the body needs to rid itself of cholesterol and discarded hormonal remnants, via gall and poop. If your liver and gall aren't functioning right the waste is not transported out. This remaining waste taxes the system. I.e. causes the body stress and causes brain fog.

Another cause of brain fog is heavy metals. These might come loose due to the HC? this is a though I just had.
I know Copper loosens up and starts floating around the brain when you take Zinc.
I know HC influences brain chemistry.
Again, your body must be able to clear the waste otherwise the waste will interfere with normal cell functioning.

I take Fludro, it's for ridiculous low blood pressure. Fludrocortisone = Aldosterone = mineral corticosteroid.
HC = gluco corticosteroid. Both are produced in the adrenals and are made from Cholesterol --> Progesteron --> corticosteroids.

3. I tried to search this but couldn't find much information, but is there a relationship between HC and things like food intolerances, MCAS etc.? Just curious because I'm continuing eating 'bad' foods like peanut butter because I don't want to put my body in a zero carb state, especially while trying the HC, but just wondering if these intolerances could improve at all.
I get massively nauseous when my HC is too low. (logic: stomach acid is governed by cortisol. Not enough cortisol = not enough acid = hard to digest proteins and fats). But you're not talking about nausea, are you?

Cortisol dampens the immune system. With not enough cortisol your immune system will behave like a diva and trigger on a lot of things. Perhaps on foodstuff too?
Stress stimulates cortisol. Stressed people get vulnerable to virus infections because their high cortisol dampens their immune system.
(unless they are on their way to a burn out, then their cortisol levels are erratic)

I figure that taking HC dampens the immune system so if you take more than your body needs the immune system may not trigger massively on foods like it did before.

Are you intolerant to peanut butter?

So, taking HC while you are in one of the adrenal fatigue stages mentioned by dr. Selye gives so much variables that it's hard to connect one thing to just one other thing.
There are so any variables. You are like a blindfolded man trying to identify instruments while the whole orchestra is tooting. But as long as the whole lot doesn't crash trough the stage floor you're doing ok.
 

outdamnspot

Senior Member
Messages
813
Likes
571
@WoolPippi I wasn't sure if you're around at the moment but I had a question, and sorry for not answering your other questions. For what it's worth, HC hasn't had any positive effect on my food intolerances/sensitivities but when I do experience a crash from eating a bad food, it can spare me from becoming completely disabled.

And yes, I am intolerant to peanut butter but I find my intolerances cycle (e.g. I might be okay with a food after abstaining for a few weeks, but the if I eat too much I get sick from it again).

What I was wondering at the moment is: I have had to work up to about 20mg of HC a day, because 5mg was just not cutting it at all. I tend to take 10mg upon waking, about 5mg a few hours later and then 5mg after dinner, which is my first meal (remember, my sleep cycle is shifted). What I find is that the last dinner dose (taken about 8.30pm) will wear off at about midnight. Then I crash again and am left in the horrible low cortisol/adrenaline state for 4-5 hours until bedtime at 5am. I've read you say that you take a dose before bed, and I actually have the same sleeping issue as you (tend to wake up after a few hours of dreaming with panic/adrenaline for an hour, then can fall back asleep).

I don't really find HC stimulating -- it's more relaxing if anything, though makes me feel more 'awake'. I'm wondering if it's okay to take a little dose to cover me until bed .. i.e should the HC only really be doing it's job for the 3 hours it's in your body, or can it end up disturbing sleep if taken too late? I did experiment with a small dose (about 2.5mg) taken at midnight and it stopped me feeling awful until bed, and then I could feel it wearing off again right before sleep. I did sleep poorly but that may have been related to a food reaction. So I guess my question is whether HC is only really in effect for the 3 hours it's in the body, i.e. should the particular time it's taken not really matter?
 

taniaaust1

Senior Member
Messages
12,716
Likes
14,648
Location
Sth Australia
What I was wondering at the moment is: I have had to work up to about 20mg of HC a day, because 5mg was just not cutting it at all. I tend to take 10mg upon waking, about 5mg a few hours later and then 5mg after dinner, which is my first meal (remember, my sleep cycle is shifted). What I find is that the last dinner dose (taken about 8.30pm) will wear off at about midnight. Then I crash again and am left in the horrible low cortisol/adrenaline state for 4-5 hours until bedtime at 5am. I've read you say that you take a dose before bed, and I actually have the same sleeping issue as you (tend to wake up after a few hours of dreaming with panic/adrenaline for an hour, then can fall back asleep).

I don't really find HC stimulating -- it's more relaxing if anything, though makes me feel more 'awake'. I'm wondering if it's okay to take a little dose to cover me until bed .. i.e should the HC only really be doing it's job for the 3 hours it's in your body, or can it end up disturbing sleep if taken too late? I did experiment with a small dose (about 2.5mg) taken at midnight and it stopped me feeling awful until bed, and then I could feel it wearing off again right before sleep. I did sleep poorly but that may have been related to a food reaction. So I guess my question is whether HC is only really in effect for the 3 hours it's in the body, i.e. should the particular time it's taken not really matter?
I find it concerning that you are taking as much as 20mg while you are not under the care of a dr. The ME/CFS specialists I know who have prescribed HC to some of their patients, tended to prescribe it as low does at only 5-10 mg per day and that is what my own dr did at one point. (I did actually have out of normal range low cortisol showing up on a couple of my test results or had it as showing being borderline 3 out of 4 of my urine cortisol test results were borderline or low).

Even low does HC can end up causing issues.
 

WoolPippi

Senior Member
Messages
555
Likes
1,518
Location
Netherlands
@WoolPippi I wasn't sure if you're around at the moment but I had a question, and sorry for not answering your other questions. For what it's worth, HC hasn't had any positive effect on my food intolerances/sensitivities but when I do experience a crash from eating a bad food, it can spare me from becoming completely disabled.

And yes, I am intolerant to peanut butter but I find my intolerances cycle (e.g. I might be okay with a food after abstaining for a few weeks, but the if I eat too much I get sick from it again).

What I was wondering at the moment is: I have had to work up to about 20mg of HC a day, because 5mg was just not cutting it at all. I tend to take 10mg upon waking, about 5mg a few hours later and then 5mg after dinner, which is my first meal (remember, my sleep cycle is shifted). What I find is that the last dinner dose (taken about 8.30pm) will wear off at about midnight. Then I crash again and am left in the horrible low cortisol/adrenaline state for 4-5 hours until bedtime at 5am. I've read you say that you take a dose before bed, and I actually have the same sleeping issue as you (tend to wake up after a few hours of dreaming with panic/adrenaline for an hour, then can fall back asleep).

I don't really find HC stimulating -- it's more relaxing if anything, though makes me feel more 'awake'. I'm wondering if it's okay to take a little dose to cover me until bed .. i.e should the HC only really be doing it's job for the 3 hours it's in your body, or can it end up disturbing sleep if taken too late? I did experiment with a small dose (about 2.5mg) taken at midnight and it stopped me feeling awful until bed, and then I could feel it wearing off again right before sleep. I did sleep poorly but that may have been related to a food reaction. So I guess my question is whether HC is only really in effect for the 3 hours it's in the body, i.e. should the particular time it's taken not really matter?
Hi, sounds like you're benefitting from the HC. You are supplementing the anti-stress hormones your body lacks and your body is able to relax a bit more. Sounds like you are appropriatly cautious and are not overdoing it. I like your approach (but I'm no doctor! and I have warned you time and time again how dangerous it is what you are doing. you are on your own here.)

Yes it's only in effect for the 3 to 4 hours it is in your body.
We try to mimic the natural curve with a high doses in the morning and not so much at night, just you are doing. I think another dose at midnight will work for you, just to get your body out of that crazed panic state. You may indeed need more than 20 mg per day. I myself need 35 mg per day when I'm out and about and at work and taking a long walk in the winter cold. I need 17,5 mg per day when I spend the day in bed.

You are taking a body-identical molecule and your body cannot distinquish whether it was ingested or home made. At your current dose you are now interfering with your own producing glands, which weren't doing a good job anyway. You can go higher than 20 mg per day, you have to find what works for you. But beware: since you are now interfering with your hormonal system Do Not, ever, Quit Cold Turkey.

Whenever in the future you decide to lower you doses do so in 5 mg per day steps over one week. Next week take off another 5 mg. Even slower. You have to try and see if your own adrenals come online again.
If they do not you have to take HC for the rest of your life. (please contemplate what this means. You will need a supplier for the rest of your days. Money to buy it. If a war starts or civilisation collapses we're fucked.)

I do not take a dose before sleep, my last one (2,5 mg) is at 19.30 hours and then I get overwhelmed by my own melatonin at 21.30 hours. If I take a dose later than 19.30 hours I'll ride another cortisol wave and won't get sleepy until 1 o'clock. You can experiment how your body reacts with 2,5 mg at various times. Experiments are temporal. You want to find out how much you need at what times to get out of that zombie-feeling.

My waking at night is due to digestive troubles, it seems I can only lie 4,5 hours and then a gas bubble will get stuck in the tubes and cause a stress reaction. I lie wide awake for one hour, if it's 5 o'clock or later I can take 2 mg HC and 15 minutes later my body relaxes and I can get another hour of sleep. If it's before 5 o'clock HC will keep me awake until 7 o'clock and my day is wrecked. Something for you to experiment with?

I have stopped eating btw, to diminish any gas or bulk in the colon. I'm on cream, chicken stock and egg yokes and tea and one coffee per day. Sometimes I now sleep 6 hours in one stretch and my wakings are not so violent and sweaty anymore. Then my day is glorious.

One more thing: at this dose of HC your body consumes electrolytes and minerals at a faster rate. You need extra Sodium which may lead to low Kalium. Zinc is certainly needed. Magnesium too. The HC might rob your bones from Calcium but there's no way to find out unless you do a DEXA-scan. You blood level of Calcium will look normal so that's nothing to go on. A doctor would have your various blood levels checked every 3 months. Mine does. Electrolytes, hormones, the works.

I am glad you are feeling a bit better. Or feeling less wrecked.
 

outdamnspot

Senior Member
Messages
813
Likes
571
I find it concerning that you are taking as much as 20mg while you are not under the care of a dr. The ME/CFS specialists I know who have prescribed HC to some of their patients, tended to prescribe it as low does at only 5-10 mg per day and that is what my own dr did at one point. (I did actually have out of normal range low cortisol showing up on a couple of my test results or had it as showing being borderline 3 out of 4 of my urine cortisol test results were borderline or low).

Even low does HC can end up causing issues.
Well, it bothers me too. But as I said in my initial post, I had kind of reached a crisis point in December -- I was almost completely bedridden/immobilized, crashing from every tiny activity, could barely eat, left by my family to completely take care of myself (cook, sometimes buy food etc.) and had no way to eliminate the amount of stress and noise I face daily, because the more sick I get, the more threatening/abusive my mother becomes, and on top of that, our house is so small that every single noise bleeds into my room and triggers a crash. My doctor is nice but when I was actually well enough to see her, she didn't grasp how seriously ill I've become and shrugged off my suggestion for hospitalization; she referred me to a specialist for my GI issues, but the HC hasn't rendered me well enough to go back to a doctor.

So without sounding too dramatic, I'm reasonably convinced I would not still be here if I hadn't started the HC, because it's given my body some means to cope with the non-stop traumatic daily stress and also cook etc. But I don't really see a solution for myself anyway; the social system is broken (especially as a non Australian citizen) and I'm not going to be placed in some special care that will allow me to recover; the testing I've done hasn't shown anything; if I was lucky enough to be hospitalized, I'd probably get pulled off HC and/or be diagnosed with an eating disorder due to my severe food intolerances. So I can't really see what can be done. I'm just thankful it's rendering me a little more functional for the time being.
 

Wayne

Senior Member
Messages
3,354
Likes
4,164
Location
Ashland, Oregon
Even low does HC can end up causing issues.
I appreciate your concerns, but wanted to mention I've been taking about 20 mg/day of HC for going on 20 years now. I've noticed no ill effects, but a lot of positive ones: 1) Better digestion; 2) Better sleep; 3) Better ability to relax; 4) Increased ability to walk; Better OI; and probably a few more.

I really don't worry about my dosage as it doesn't shut down my normal cortisol production. The average person makes about 40 mg/day, so if you keep supplemental HC below that, a person shouldn't have problems with their adrenals shutting down. That said, what works extremely well for some (like me), may not work for others. From what I can gather, @outdamnspot seems to be getting the adrenal support he needs at 20 mg/day w/ no drawbacks. That's been my experience for the past 20 years or so.
 

Mel9

Senior Member
Messages
877
Likes
2,349
Location
NSW Australia
@outdamnspot

I hear the yearning, too.

As far as I know, being a few months out of expiry isn't a big deal. Expiry dates are set very conservatively in order to protect the manufacturer and the seller, so I wouldn't even assume that it will be weaker as a result. So start with @WoolPippi 's 2.5 - 5 mg dosing, yes?

In fact, start with the 2.5mg dose and see what that does before boosting to 5.0mg.


And if you start on the HC, DON'T TAKE LICORICE..... it'll potentiate the HC and you'll have no idea what caused what, and the what may be unpleasant.
I’m glad I found this thread. Thanks to Pippi et al.

I have just discovered my 24h urine cortisol is low so next week I start taking 10mg HC as prescribed by my doctor. Just to play safe, I wonder if I should halve that for a while?.
 
Messages
1,977
Likes
5,257
Location
Second star to the right ...
@Mel9
I;m not n the greatest shape today, brain-foggy, but I think I recall that @WoolPippi said that the HC effect lasted for about 3.5 to 4 hours, and was best taken in the AM for at least the first dose. It might not hurt to split the 10 mg's into 2 doses of 5 mg's, one dose in the AM, 2nd dose maybe before lunch, thereby spreading the effects of the HC over a longer period.

I regard @WoolPippi as an enormously informed and very smart source of info on this, and many other, substances and issues. If you have the oomph today, you might want to go back thru this thread and review all of her posts regarding this. Invaluable.

Hope you're doing well :hug:
:hug: :hug:
 

Wayne

Senior Member
Messages
3,354
Likes
4,164
Location
Ashland, Oregon
Just to play safe, I wonder if I should halve that for a while?.
Hi @Mel9 -- From my understanding, and more importantly, from my own experience, I would say that appropriate dosages are almost impossible to intellectualize. You just have to experiment, and see what your body is telling you. I generally average 20 mg/day, but I sometimes take more, and sometimes take less (though not too often).

I was particularly sensitive to HC when I first started, and even 5 mg was too much. But it only took me 2-3 days for my body to adjust to it, and then 5 mg at a time was fine. After about a week, I was doing fine on 20 mg/day, and have enjoyed the benefits since then.

Supplemental HC (Cortef) It literally changed my life, and quickly shifted my overall functionality from about 4% to about 10-15% (even though I still had CFS). It was at that time I stopped wondering at night whether I would survive until the morning.

Listen to your body carefully. -- And all the best with your foray into taking supplemental HC!
 

WoolPippi

Senior Member
Messages
555
Likes
1,518
Location
Netherlands
From my understanding, and more importantly, from my own experience, I would say that appropriate dosages are almost impossible to intellectualize. You just have to experiment, and see what your body is telling you. I generally average 20 mg/day, but I sometimes take more, and sometimes take less (though not too often).
This is my experience too, and also my understanding :thumbsup:

And it's what I base my sage words upon, @YippeeKi YOW !! May I come down from the celebration chair now? I feel awkward:balloons:

I was particularly sensitive to HC when I first started, and even 5 mg was too much. But it only took me 2-3 days for my body to adjust to it, and then 5 mg at a time was fine. After about a week, I was doing fine on 20 mg/day, and have enjoyed the benefits since then.
I took a little longer, stayed on 5 mg for about two months.
Didn't get functional until 17,5 mg though.
Didn't flourish until 25-35 mg per day.
Overdid it at 50 mg per day.

Supplemental HC (Cortef) It literally changed my life, and quickly shifted my overall functionality from about 4% to about 10-15% (even though I still had CFS). It was at that time I stopped wondering at night whether I would survive until the morning.
same. I had to get HC shoved into my mouth in the morning or I couldn't open my eyes. Virtual no glucose to the brain, it seemed?
Sometimes this still happens, even though I'm at good replacement levels every day. But the manufacturer stopped producing and now pharmacies have to produce and there was an unreliable batch I think (due to hot weather).

Listen to your body carefully.
This. So much this. Get to know the system you're working with. Your sensitivities, your symptoms. Learn what levers and dials you are dealt and start tweaking. This works for supplements, this works for hormones, this works for digestion.
 
Messages
1,977
Likes
5,257
Location
Second star to the right ...
@WoolPippi
May I come down from the celebration chair now? I feel awkward:balloons:
What? And miss the :cake::cake::cake: and :wine::wine:, and of course, the Coronation Ceremony?

Well, if you think you should. (I'd insert a clever emoji here, but they took most of the good ones away, and the new ones are flat, one-dimensional, and totally charm free).

Get to know the system you're working with. Your sensitivities, your symptoms. Learn what levers and dials you are dealt and start tweaking. This works for supplements, this works for hormones, this works for digestion.
So completely, totally true. Think of it as internal sleuthing. The effort to find and define the culprits, learn how they work, cut the ground out from under them, find the good stuff allies and support.

We dismiss the metaphysical body/mind connection at our own peril. And loss.
 
Last edited: